ETHYL 2-NITROPROPIONATE Property

Boiling point:

75-76 °C/9 mmHg (lit.)

Density 

1.13 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.421(lit.)

Flash point:

193 °F

pka

5.98±0.10(Predicted)

Water Solubility 

Not miscible in water.

BRN 

774734

EPA Substance Registry System

Propanoic acid, 2-nitro-, ethyl ester (2531-80-8)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

ETHYL 2-NITROPROPIONATE Chemical Properties,Usage,Production

Uses

Ethyl 2-nitropropionate is used in the preparation of (-)-trans-2,5-dimethylprolineethyl ester via enantioselective Michael reaction methyl vinyl ketone using modified dihydroquinine as catalyst, novel nitrogen-15-labeled nitrone spin trap, 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide ([15N]EMPO) for detecting superoxide anion, 2-ethoxycarbonyl-2-nitropentanal. It is used for enantioselective Michael reactions.

Uses

Ethyl 2-nitropropionate was used in the preparation of:

• (?)-trans-2,5-dimethylprolineethyl ester via enantioselective Michael reaction methyl vinyl ketone using modified dihydroquinine as catalyst
• novel nitrogen-15-labeled nitrone spin trap, 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide ([¹⁵N]EMPO) for detecting superoxide anion
• 2-ethoxycarbonyl-2-nitropentanal

General Description

Ethyl 2-nitropropionate is a nitro ester.